Systemic inflammation interferes with learning and memory processes and may contribute to the pathophysiology of chronic pain by impairing the extinction of pain-related fear. This project aims to analyze the effects of acute and chronic inflammation on different aspects of extinction learning. We will test in healthy volunteers if acute inflammation, experimentally induced by intravenous administration of endotoxin, impairs extinction and facilitates reinstatement of conditioned pain-related fear. Effects of chronic inflammation on extinction learning will be addressed in patients with chronic inflammatory bowel disease.
Guiding questions of A12:
Benson S, Rebernik L, Wegner A, Kleine-Borgmann J, Engler H, Schlamann M, Forsting M, Schedlowski M, Elsenbruch S (2015) Neural circuitry mediating inflammation-induced central pain amplification in human experimental endotoxemia. Brain Behav Immun. 48: 222–231. doi:10.1016/j.bbi.2015.03.017
Elsenbruch S, Rosenberger C, Bingel U, Forsting M, Schedlowski M, Gizewski E Altered emotional modulation of the neural response to visceral stimuli in irritable bowel syndrome. Gastroenterology. 2010(139): 1310–1319.
Engler H, Benson S, Wegner A, Spreitzer I, Schedlowski M, Elsenbruch S (2016) Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms. Brain Behav Immun. 52: 18–26. doi:10.1016/j.bbi.2015.08.013
Engler H, Doenlen R, Engler A, Riether C, Prager G, Niemi M-B, Pacheco-Lopez G, Krugel U, Schedlowski M (2011) Acute amygdaloid response to systemic inflammation. Brain Behav Immun. 25(7): 1384–1392. doi:10.1016/j.bbi.2011.04.005
Grigoleit J-S, Kullmann JS, Oberbeck R, Schedlowski M, Engler H (2013) Salivary alpha-amylase response to endotoxin administration in humans. Psychoneuroendocrinology. 38(9): 1819–1823. doi:10.1016/j.psyneuen.2013.01.003
Hadamitzky M, Bösche K, Engler A, Schedlowski M, Engler H (2015) Extinction of conditioned taste aversion is related to the aversion strength and associated with c-fos expression in the insular cortex. Neuroscience. 303: 34–41. doi:10.1016/j.neuroscience.2015.06.040
Icenhour A, Kattoor J, Benson S, Boekstegers A, Schlamann M, Merz CJ, Forsting M, Elsenbruch S (2015) Neural circuitry underlying effects of context on human pain-related fear extinction in a renewal paradigm. Hum Brain Mapp. 36(8): 3179–3193. doi:10.1002/hbm.22837
Labrenz F, Icenhour A, Schlamann M, Forsting M, Bingel U, Elsenbruch S (2016) From Pavlov to pain: How predictability affects the anticipation and processing of visceral pain in a fear conditioning paradigm. Neuroimage. 130: 104–114. doi:10.1016/j.neuroimage.2016.01.064
Prager G, Hadamitzky M, Engler A, Doenlen R, Wirth T, Pacheco-Lopez G, Krugel U, Schedlowski M, Engler H (2013) Amygdaloid signature of peripheral immune activation by bacterial lipopolysaccharide or staphylococcal enterotoxin B. J Neuroimmune Pharmacol. 8(1): 42–50. doi:10.1007/s11481-012-9373-0
Schmid J, Langhorst J, Gass F, Theysohn N, Benson S, Engler H, Gizewski ER, Forsting M, Elsenbruch S (2015) Placebo analgesia in patients with functional and organic abdominal pain: a fMRI study in IBS, UC and healthy volunteers. Gut. 64(3): 418–427. doi:10.1136/gutjnl-2013-306648