We will study factors that potentially influence the strength of the renewal effect of extinction: i.e. external (context-related) and internal (structural and process-related) potential moderators of renewal. By manipulating the saliency and generalizability of contexts, we aim to alter context processing and thus the level of renewal. By means of pharmacological intervention, we will modulate initial learning of associations to investigate potential effects upon renewal. Using various neuroimaging methods, we will relate task-associated activation in extinction-relevant brain regions, functional and structural connectivity as well as structural brain features to the propensity of showing renewal.
Guiding questions of A08:
Our proposed studies will extend the present knowledge about the mechanisms of the context-related recovery of extinguished responses and thus can provide new insights for therapeutic interventions.
Chang D-I, Lissek S, Ernst TM, Thürling M, Uengoer M, Tegenthoff M, Ladd ME, Timmann D (2015) Cerebellar Contribution to Context Processing in Extinction Learning and Recall. Cerebellum. 14(6): 670–676. doi:10.1007/s12311-015-0670-z
Kinner VL, Merz CJ, Lissek S, Wolf OT (2016) Cortisol disrupts the neural correlates of extinction recall. Neuroimage. 133: 233–243. doi:10.1016/j.neuroimage.2016.03.005
Lissek S, Güntürkün O (2003) Dissociation of extinction and behavioral disinhibition: the role of NMDA receptors in the pigeon associative forebrain during extinction. J Neurosci. 23(22): 8119–8124.
Lissek S, Güntürkün O (2005) Out of context: NMDA receptor antagonism in the avian ‘prefrontal cortex’ impairs context processing in a conditional discrimination task. Behav Neurosci. 119(3): 797–805.
Lissek S, Glaubitz B, Güntürkün O, Tegenthoff M (2015) Noradrenergic stimulation modulates activation of extinction-related brain regions and enhances contextual extinction learning without affecting renewal. Front Behav Neurosci. 9: 34. doi:10.3389/fnbeh.2015.00034
Lissek S, Glaubitz B, Schmidt-Wilcke T, Tegenthoff M (2016) Hippocampal Context Processing during Acquisition of a Predictive Learning Task Is Associated with Renewal in Extinction Recall. J Cogn Neurosci. 28(5): 747–762. doi:10.1162/jocn_a_00928
Lissek S, Glaubitz B, Uengoer M, Tegenthoff M (2013) Hippocampal activation during extinction learning predicts occurrence of the renewal effect in extinction recall. Neuroimage. 81: 131–143. doi:10.1016/j.neuroimage.2013.05.025
Lissek S, Glaubitz B, Wolf OT, Tegenthoff M (2015) The DA antagonist tiapride impairs context-related extinction learning in a novel context without affecting renewal. Front Behav Neurosci. 9: 238. doi:10.3389/fnbeh.2015.00238
Meir Drexler S, Merz CJ, Hamacher-Dang TC, Tegenthoff M, Wolf OT (2015) Effects of Cortisol on Reconsolidation of Reactivated Fear Memories. Neuropsychopharmacology. 40(13): 3036–3043. doi:10.1038/npp.2015.160
Schwabe L, Hoffken O, Tegenthoff M, Wolf OT (2013) Opposite effects of noradrenergic arousal on amygdala processing of fearful faces in men and women. Neuroimage. 73: 1–7.