A01 A02 A03 A04 A05 A07 A09 A10 A11 A12 A13 A14 A18 A19 A21 F01 F02

A08 – Structural, process- and context-related factors mediating the renewal effect of extinction

Silke Lissek, Martin Tegenthoff

We will study factors that potentially influence the strength of the renewal effect of extinction: i.e. external (context-related) and internal (structural and process-related) potential moderators of renewal. By manipulating the saliency and generalizability of contexts, we aim to alter context processing and thus the level of renewal. By means of pharmacological intervention, we will modulate initial learning of associations to investigate potential effects upon renewal. Using various neuroimaging methods, we will relate task-associated activation in extinction-relevant brain regions, functional and structural connectivity as well as structural brain features to the propensity of showing renewal.

Guiding questions of A08:

  • To what degree can structural or process-related moderators predict the probability of showing renewal?
  • Can renewal be intensified or reduced by modulating context-related moderators such as salience or generalizability, with corresponding effects upon brain activation patterns?

Our proposed studies will extend the present knowledge about the mechanisms of the context-related recovery of extinguished responses and thus can provide new insights for therapeutic interventions.

Anne Klass

Postdoc A08

Ruhr-Universität Bochum

Silke Lissek

Projektleiterin A08

Ruhr-Universität Bochum

Martin Tegenthoff

Projektleiter A08

Ruhr-Universität Bochum

Alina Nostadt

Doktorandin A08

Ruhr-Universität Bochum

10 project-relevant publications

Chang D-I, Lissek S, Ernst TM, Thürling M, Uengoer M, Tegenthoff M, Ladd ME, Timmann D (2015) Cerebellar Contribution to Context Processing in Extinction Learning and Recall. Cerebellum. 14(6): 670–676. doi:10.1007/s12311-015-0670-z

Kinner VL, Merz CJ, Lissek S, Wolf OT (2016) Cortisol disrupts the neural correlates of extinction recall. Neuroimage. 133: 233–243. doi:10.1016/j.neuroimage.2016.03.005

Lissek S, Güntürkün O (2003) Dissociation of extinction and behavioral disinhibition: the role of NMDA receptors in the pigeon associative forebrain during extinction. J Neurosci. 23(22): 8119–8124.

Lissek S, Güntürkün O (2005) Out of context: NMDA receptor antagonism in the avian ‘prefrontal cortex’ impairs context processing in a conditional discrimination task. Behav Neurosci. 119(3): 797–805.

Lissek S, Glaubitz B, Güntürkün O, Tegenthoff M (2015) Noradrenergic stimulation modulates activation of extinction-related brain regions and enhances contextual extinction learning without affecting renewal. Front Behav Neurosci. 9: 34. doi:10.3389/fnbeh.2015.00034

Lissek S, Glaubitz B, Schmidt-Wilcke T, Tegenthoff M (2016) Hippocampal Context Processing during Acquisition of a Predictive Learning Task Is Associated with Renewal in Extinction Recall. J Cogn Neurosci. 28(5): 747–762. doi:10.1162/jocn_a_00928

Lissek S, Glaubitz B, Uengoer M, Tegenthoff M (2013) Hippocampal activation during extinction learning predicts occurrence of the renewal effect in extinction recall. Neuroimage. 81: 131–143. doi:10.1016/j.neuroimage.2013.05.025

Lissek S, Glaubitz B, Wolf OT, Tegenthoff M (2015) The DA antagonist tiapride impairs context-related extinction learning in a novel context without affecting renewal. Front Behav Neurosci. 9: 238. doi:10.3389/fnbeh.2015.00238

Meir Drexler S, Merz CJ, Hamacher-Dang TC, Tegenthoff M, Wolf OT (2015) Effects of Cortisol on Reconsolidation of Reactivated Fear Memories. Neuropsychopharmacology. 40(13): 3036–3043. doi:10.1038/npp.2015.160

Schwabe L, Hoffken O, Tegenthoff M, Wolf OT (2013) Opposite effects of noradrenergic arousal on amygdala processing of fearful faces in men and women. Neuroimage. 73: 1–7.