In this project we will explore the specific interaction between the anterior network (hippocampus, amygdala, prefrontal cortex) and the cerebellum during extinction (study 1), develop non-invasive brain stimulation protocols suited for targeted modulation of extinction-relevant areas identified in that study (study 2), apply these to explore the causality of respective physiological interactions for extinction (study 3), and reveal cellular mechanisms of respective target structures for extinction by combining pharmacology (relevance of serotonin) and stimulation (study 4).
Guiding questions of A06:
Agboada D, Mosayebi-Samani M, Kuo MF, Nitsche MA (2020) Induction of long-term potentiation-like plasticity in the primary motor cortex with repeated anodal transcranial direct current stimulation–Better effects with intensified protocols? Brain Stimul. 13: 987–997.
Batsikadze G, Rezaee Z, Chang DI, Gerwig M, Herlitze S, Dutta A, Nitsche MA, Timmann D (2019) Effects of cerebellar transcranial direct current stimulation on cerebellar-brain inhibition in humans: A systematic evaluation. Brain Stimul. 12:1177–1186.
Klauss J, Anders QS, Felippe LV, Nitsche MA, Nakamura-Palacios EM (2018) Multiple sessions of transcranial direct current stimulation (tDCS) reduced craving and relapses for alcohol use: A randomized placebo-controlled trial in alcohol use disorder. Front Pharmacol. 9: 716.
Monte-Silva K, Kuo MF, Hessenthaler S, Fresnoza S, Liebetanz D, Paulus W, Nitsche MA (2013) Induction of late LTP-like plasticity in the human motor cortex by repeated non-invasive brain stimulation. Brain Stimul. 6: 424–32.
Nejati V, Salehinejad MA, Nitsche MA (2018) Interaction of the left dorsolateral prefrontal cortex (l-DLPFC) and right orbitofrontal cortex (OFC) in hot and cold executive functions: Evidence from transcranial direct current stimulation (tDCS). Neuroscience. 369: 109–123.
Rostami R, Kazemi R, Jabbari A, Madani AS, Rostami H, Taherpour MA, Molavi P, Jaafari N, Kuo MF, Vicario CM, Nitsche MA, Salehinejad MA (2020) Efficacy and clinical predictors of response to rTMS treatment in pharmacoresistant obsessive-compulsive disorder (OCD): a retrospective study. BMC Psychiatry. 20: 372.
Shahbabaie A, Hatami J, Farhoudian A, Ekhtiari H, Khatibi A, Nitsche MA (2018) Optimizing electrode montages of transcranial direct current stimulation for attentional bias modification in early abstinent methamphetamine users. Front Pharmacol. 9: 907.
Vicario CM, Nitsche MA, Hoysted I, Yavari F, Avenanti A, Salehinejad MA, Felmingham KL (2020) Anodal transcranial direct current stimulation over the ventromedial prefrontal cortex enhances fear extinction in healthy humans: A single blind sham-controlled study. Brain Stimul. 13: 489–491.
Vicario CM, Salehinejad MA, Felmingham K, Martino G, Nitsche MA (2019) A systematic review on the therapeutic effectiveness of non-invasive brain stimulation for the treatment of anxiety disorders. Neurosci Biobehav Rev. 96: 219–231.