A01 A02 A03 A04 A05 A07 A09 A10 A11 A12 A13 A14 A18 A19 A21 F01 F02

A05 – The contribution of the cerebellum to extinction: intrinsic mechanisms and cerebello-cerebral interactions

Dagmar Timmann-Braun, Harald H. Quick

Project A05 includes three 7T fMRI studies, two 3T fMRI studies and one behavioral study. Two of the 7T fMRI experiments (study 1 and 2) will be performed in the first two years of funding. The behavioral study (study 5) will start during the first year. The 3T fMRI experiments (study 3 and 4) will start in the second year. Study 3 makes use of the optimized cerebellar tDCS parameters established in the first year in A06. Study 4 will be performed in cerebellar patients. We expect data acquisition of studies 3–5 to be finished by the end of the third year. In the fourth year the tDCS set-up will be brought to the 7T MR scanner (study 6).

Guiding questions of A05:

  • Does the human cerebellum, more specifically the cerebellar vermis and the fastigial nuclei, contribute to the extinction of conditioned fear?
  • What are the intrinsic cerebellar mechanisms underlying extinction?
  • Does the cerebellum interact with cerebral areas, in particular the amygdala, hippocampus and prefrontal cortex, during extinction?
  • Do the posterolateral cerebellar hemispheres and vermis play a different role in extinction?
  • Can the proposed intrinsic cerebellar mechanisms and cerebello-cerebral interactions be modulated by cerebellar transcranial direct current stimulation (tDCS) and by cerebellar dependent motor learning?
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Dagmar Timmann-Braun

Projektleiterin A05, F02

Universität Duisburg-Essen

Harald-H. Quick

Projektleiter A05, F02

Universität Duisburg-Essen

Giorgi Batsikadze

Postdoc A05

Universität Duisburg-Essen

Thomas Ernst

Postdoc A05

Universität Duisburg-Essen

Bilge Albayrak

Postdoc A05 (assoziiert)

UK Essen - Klinik für Kinderheilkunde I

Lana Inoue

Doktorandin A05

Universität Duisburg-Essen

Michael Klein

Doktorand A05

Universität Duisburg-Essen

Alice Doubliez

Doktorandin A05

Universität Duisburg-Essen

Enzo Nio

Doktorand A05

Universität Duisburg-Essen

10 project-relevant publications

Diedrichsen J, Maderwald S, Kuper M, Thürling M, Rabe K, Gizewski ER, Ladd ME, Timmann D (2011) Imaging the deep cerebellar nuclei: a probabilistic atlas and normalization procedure. Neuroimage. 54(3): 1786–1794.doi:10.1016/j.neuroimage.2010.10.035

Gratz M, Schlamann M, Goericke S, Maderwald S, Quick HH (2016) Evaluation of fast highly undersampled contrastenhanced MR angiography (sparse CE-MRA) in intracranial applications – initial study. Eur Radiol.doi:10.1007/s00330-016-4398-z

Maschke M, Drepper J, Kindsvater K, Kolb FP, Diener HC, Timmann D (2000) Fear conditioned potentiation of the acoustic blink reflex in patients with cerebellar lesions. J Neurol Neurosurg Psychiatry. 68(3): 358–364.

Maschke M, Schugens M, Kindsvater K, Drepper J, Kolb FP, Diener HC, Daum I, Timmann D (2002) Fear conditioned changes of heart rate in patients with medial cerebellar lesions. J Neurol Neurosurg Psychiatry. 72(1): 116–118.

Rietsch SHG, Quick HH, Orzada S (2015) Impact of different meander sizes on the RF transmit performance and coupling of microstrip line elements at 7 T. Med Phys. 42(8): 4542–4552. doi:10.1118/1.4923177 Stefanescu MR, Dohnalek M, Maderwald S, Thürling M, Minnerop M, Beck A, Schlamann M, Diedrichsen J, Ladd ME, Timmann D (2015) Structural and functional MRI abnormalities of cerebellar cortex and nuclei in SCA3, SCA6 and Friedreich’s ataxia. Brain. 138(Pt 5): 1182–1197. doi:10.1093/brain/awv064

Thieme A, Thürling M, Galuba J, Burciu RG, Goricke S, Beck A, Aurich V, Wondzinski E, Siebler M, Gerwig M, Bracha V, Timmann D (2013) Storage of a naturally acquired conditioned response is impaired in patients with cerebellar degeneration. Brain. 136(Pt 7): 2063–2076. doi:10.1093/brain/awt107

Thürling M, Kahl F, Maderwald S, Stefanescu RM, Schlamann M, Boele H-J, Zeeuw CI de, Diedrichsen J, Ladd ME,

Koekkoek SKE, Timmann D (2015) Cerebellar cortex and cerebellar nuclei are concomitantly activated during eyeblink conditioning: a 7T fMRI study in humans. J Neurosci. 35(3): 1228–1239. doi:10.1523/JNEUROSCI.2492-14.2015

Voelker MN, Kraff O, Brenner D, Wollrab A, Weinberger O, Berger MC, Robinson S, Bogner W, Wiggins C, Trampel R, Stocker T, Niendorf T, Quick HH, Norris DG, Ladd ME, Speck O (2016) The traveling heads: multicenter brain imaging at 7 Tesla. MAGMA. 29(3): 399–415. doi:10.1007/s10334-016-0541-8

Zuchowski ML, Timmann D, Gerwig M (2014) Acquisition of conditioned eyeblink responses is modulated by cerebellar tDCS. Brain Stimul. 7(4): 525–531. doi:10.1016/j.brs.2014.03.010