Using advanced imaging methods in humans we will test how dynamic interactions between core regions of the extinction network shape learning. Here, we investigate how progress in fear extinction alters functional fMRI connectivity within the network. Simultaneous EEG/fMRI recordings will reveal the electrophysiological origins of these connectivity changes. Also, interindividual differences in learning outcome will be related to variations of pre-learning structural network connectivity. Finally, high-resolution fMRI recordings at 7T will uncover for the first time the importance of fine-grained functional and structural network interactions between distinct amygdala nuclei and other regions of the network on extinction learning.
Guiding questions of A03:
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