While extinction is context-dependent, acquisition contexts generalize easily. Here, we investigate how context generalization is controlled by neural activity in core regions of the extinction network. The generalization and distinctiveness of neural context representations will be assessed via multivariate analysis methods. Combining simultaneous EEG/fMRI recordings in healthy participants with intracranial EEG and single-unit recordings in epilepsy patients, we will identify the neural mechanisms that control if contexts generalize or stay distinct, and if renewal or extinction retrieval occurs. Our data will provide a unique bridge between human neuroimaging and animal electrophysiology studies of extinction learning.
Guiding questions of A02:
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Kunz L, Wang L, Lachner-Piza D, Zhang H, Brandt A, Dümpelmann M, Reinacher PC, Coenen VA, Chen D, Wang WX, Zhou W, Liang S, Grewe P, Bien CG, Bierbrauer A, Navarro Schröder T, Schulze-Bonhage A, Axmacher N (2019) Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation. Sci Adv. 5(7): eaav8192.
Lee H, Stirnberg R, Wu S, Wang X, Stöcker T, Jung S, Montag C, Axmacher N (2020) Genetic Alzheimer’s Disease Risk Affects the Neural Mechanisms of Pattern Separation in Hippocampal Subfields. Curr Biol. 30: 4201–4212.e3.
Oehrn CR, Fell J, Baumann C, Rosburg T, Ludowig E, Kessler H, Hanslmayr S, Axmacher N (2018) Direct Electrophysiological Evidence for Prefrontal Control of Hippocampal Processing during Voluntary Forgetting. Curr Biol. 28(18): 3016–3022.e4.
Pacheco ED, Sánchez-Fibla M, Duff A, Principe A, Rocamora R, Zhang H, Axmacher N, Verschure PFMJ (2019) Coordinated representational reinstatement in the human hippocampus and lateral temporal cortex during episodic memory retrieval. Nat Commun. 10(1): 2255.
Waldhauser GT, Dahl MJ, Ruf-Leuschner M, Müller-Bamouh V, Schauer M, Axmacher N, Elbert T, Hanslmayr S (2018) The neural dynamics of deficient memory control in heavily traumatized refugees. Sci Rep. 8(1): 13132.
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