While extinction is context-dependent, acquisition contexts generalize easily. Here, we investigate how context generalization is controlled by neural activity in core regions of the extinction network. The generalization and distinctiveness of neural context representations will be assessed via multivariate analysis methods. Combining simultaneous EEG/fMRI recordings in healthy participants with intracranial EEG and single-unit recordings in epilepsy patients, we will identify the neural mechanisms that control if contexts generalize or stay distinct, and if renewal or extinction retrieval occurs. Our data will provide a unique bridge between human neuroimaging and animal electrophysiology studies of extinction learning.
Guiding questions of A02:
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