A01 A02 A03 A04 A05 A06 A07 A08 A09 A10 A11 A12 A13 A14 A15 A16 A18 F01 F02

Treasure Box Funding for Julian Packheiser (A01)

27. March 2018

Julian was excited whether his request would be granted. He has been interested in the idea behind this planned study for a long time now. Years ago he allready received a small grant from the Extinction Group for a precursor of this study and is now keen to develop his very first idea for extinction. Congratulations on approval! That’s how he explains his study plan:

Title: „The influence of memory consolidation on extinction learning and renewal“
Extinction learning is a fundamental ability for organisms in order to adapt to the ever-changing environment. It describes the capacity to modify previously learned associations that have become obsolete (Pavlov, 1927). An important finding about extinction learning is that it is not a simple process of unlearning. Several phenomena demonstrate that the initial acquisition is merely inhibited during extinction learning, not simply forgotten (Bouton, 2004). One of these phenomena is known as the renewal effect. Renewal describes the context-specificity of extinction learning. If the process of extinction takes place in a different context than the original acquisition, the originally learned behavior might reappear when an organism is put into the acquisition context again (Bouton et al., 2012).

Extinction learning paradigms are classically divided into separate phases that take place on several consecutive days (Hamacher-Dang et al., 2013). The rationale behind this separation of acquisition, extinction and a subsequent test of the extinction memory trace under various conditions is the idea that the acquired knowledge has to be consolidated before retrieval. Memory consolidation is classically associated with the necessity of protein synthesis which requires at least several hours to occur (McKenzie & Eichenbaum, 2011, Nader & Einarsson, 2010). However, this notion of memory consolidation might be too exclusive as it does not consider memory consolidation based on immediate synaptic changes. The primary objective of this study is to compare the effects of renewal with and without a time interval in between to disentangle the importance of protein synthesis based memory consolidation for the occurrence and strength of the renewal effect. This project has major implications within the scope of the current SFB 1280 as several projects rely on the absence of a passed time window before testing for the renewal effect. If this study could provide evidence that the necessity of this passage of time is not a requirement for the existence of the renewal effect, several projects could use that data to support their chosen experimental approach. The secondary objective of this study is to compare the aforementioned potential effects of memory consolidation between pigeons and humans. Given the comparative nature of many projects in the SFB 1280 using animal models, this study could also provide support for these approaches if the effects of passed time on renewal turn out to be similar in both species.

Bouton, M.E. (2004). Context and behavioral processes in extinction. Learning & Memory (Cold Spring Harbor, N.Y.) 11, 485–494.

Bouton, M. E., Winterbauer, N. E., & Todd, T. P. (2012). Relapse processes after the extinction of instrumental learning: renewal, resurgence, and reacquisition. Behavioural processes, 90(1), 130-141.

Hamacher-Dang, T., Engler, H., Schedlowski, M., & Wolf, O. T. (2013). Stress enhances the consolidation of extinction memory in a predictive learning task. Frontiers in behavioral  neuroscience, 7, 108.

McKenzie, S., & Eichenbaum, H. (2011). Consolidation and reconsolidation: two lives of memories?. Neuron, 71(2), 224-233.

Nader, K., & Einarsson, E. Ö. (2010). Memory reconsolidation: an update. Annals of the New York Academy of Sciences, 1191(1), 27-41.

Pavlov, I. P. (1927). Conditioned reflexes (G.V. Anrep, Ed. & Trans.). London: Oxford University Press.

 

 

The SFB 1280 has set up a budget for the realization of its young researchers’ own research ideas. With the “treasure chest” we finance convincing and independent study concepts of young scientists.