The impact of cortisol administration or exposure to stress on extinction processes will be tested in four domains. First, effects of cortisol on stimulus-based fear generalization during extinction will be explored using neuroimaging. Second, effects of a novel method of reactivation (presentation of the UCS) combined with cortisol administration on reconsolidation and fear generalization will be tested. Third, the influence of stress on context-dependent reinstatement will be investigated. Fourth, phase dependent stress effects on extinction of operant behavior will be characterized using appetitive and aversive consequences.
Guiding questions of A09:
Lonsdorf TB, Klingelhöfer-Jens M, Andreatta M, Beckers T, Chalkia A, Gerlicher A, Jentsch VL, Meir Drexler S, Mertens G, Richter J, Sjouwerman R, Wendt J, Merz CJ (2019) Navigating the garden of forking paths for data exclusions in fear conditioning research. ELife. 8.