The impact of cortisol administration or exposure to stress on extinction processes will be tested in four domains. First, effects of cortisol on stimulus-based fear generalization during extinction will be explored using neuroimaging. Second, effects of a novel method of reactivation (presentation of the UCS) combined with cortisol administration on reconsolidation and fear generalization will be tested. Third, the influence of stress on context-dependent reinstatement will be investigated. Fourth, phase dependent stress effects on extinction of operant behavior will be characterized using appetitive and aversive consequences.
Guiding questions of A09:
Hamacher-Dang TC, Engler H, Schedlowski M, Wolf OT (2013) Stress enhances the consolidation of extinction memory in a predictive learning task. Front Behav Neurosci. 7: 108.
Hamacher-Dang TC, Merz CJ, Wolf OT (2015) Stress following extinction learning leads to a context-dependent return of fear. Psychophysiology. 52(4): 489–498.
Hamacher-Dang TC, Uengoer M, Wolf OT (2013) Stress impairs retrieval of extinguished and unextinguished associations in a predictive learning task. Neurobiol Learn Mem. 104: 1–8.
Kinner VL, Merz CJ, Lissek S, Wolf OT (2016) Cortisol disrupts the neural correlates of extinction recall. Neuroimage. 133: 233–243.
Kinner VL, Wolf OT, Merz CJ (2016) Cortisol alters reward processing in the human brain. Horm Behav. 84: 75–83.
Meir Drexler S, Merz CJ, Hamacher-Dang TC, Tegenthoff M, Wolf OT (2015) Effects of Cortisol on Reconsolidation of Reactivated Fear Memories. Neuropsychopharmacology. 40(13): 3036–3043.
Merz CJ, Hamacher-Dang TC, Wolf OT (2014) Exposure to stress attenuates fear retrieval in healthy men. Psychoneuroendocrinology. 41: 89–96.
Mosig C, Merz CJ, Mohr C, Adolph D, Wolf OT, Schneider S, Margraf J, Zlomuzica A (2014) Enhanced discriminative fear learning of phobia-irrelevant stimuli in spider-fearful individuals. Front Behav Neurosci. 8: 328.
Schwabe L, Nader K, Wolf OT, Beaudry T, Pruessner JC (2012) Neural signature of reconsolidation impairments by propranolol in humans. Biol Psychiatry. 71(4): 380–386.
Utz A, Thürling M, Ernst TM, Hermann A, Stark R, Wolf OT, Timmann D, Merz CJ (2015) Cerebellar vermis contributes to the extinction of conditioned fear. Neurosci Lett. 604: 173–177.