Project A11 will investigate neural and behavioral mechanisms underlying the acquisition, extinction and reinstatement of pain-related fear in the context of somatic pain. We will compare patients suffering from chronic low back pain to healthy controls using a differential fear conditioning paradigm with painful heat as unconditioned stimuli (US) while collecting behavioral, physiological, neuroendocrine and neural data (MRI). The planned studies will examine (1) pain-specific aspects of fear conditioning, (2) the effects of pharmacologically induced stress on extinction recall and reinstatement and (3) neural common and distinct neural mechanisms underlying appetitive and aversive conditioning in the context of somatic pain.
Guiding questions of A11:
Bingel U, Rose M, Glascher J, Buchel C (2007) fMRI reveals how pain modulates visual object processing in the ventral visual stream. Neuron. 55: 157-167.
Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M,Tracey I (2011) The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. Sci Transl Med. 3: 70ra14.
Eippert F, Bingel U, Schoell E, Yacubian J, Buchel C (2008) Blockade of endogenous opioid neurotransmission enhances acquisition of conditioned fear in humans. J Neurosci. 28: 5465-5472.
Eippert F, Bingel U, Schoell ED, Yacubian J, Klinger R, Lorenz J, Buchel C (2009) Activation of the opioidergic descending pain control system underlies placebo analgesia. Neuron. 63: 533-543.
Forkmann K, Wiech K, Ritter C, Sommer T, Rose M, Bingel U (2013) Pain-specific modulation of hippocampal activity and functional connectivity during visual encoding. J Neurosci. 33: 2571-2581.
Forkmann K, Wiech K, Sommer T, Bingel U (2015) Reinstatement of pain-related brain activation during the recognition of neutral images previously paired with nociceptive stimuli. Pain. 156: 1501-1510.
Kessner S, Wiech K, Forkmann K, Ploner M, Bingel U (2013) The effect of treatment history on therapeutic outcome: an experimental approach. JAMA Intern Med. 173: 1468-1469.
Labrenz F, Icenhour A, Schlamann M, Forsting M, Bingel U,Elsenbruch S (2016) From Pavlov to pain: How predictability affects the anticipation and processing of visceral pain in a fear conditioning paradigm. Neuroimage. 130: 104-114.
Schmidt K, Forkmann K, Sinke C, Gratz M, Bitz A, Bingel U (2016) The differential effect of trigeminal vs. peripheral pain stimulation on visual processing and memory encoding is influenced by pain-related fear. Neuroimage. 134: 386-395.
Schwarze U, Bingel U,Sommer T (2012) Event-related nociceptive arousal enhances memory consolidation for neutral scenes. J Neurosci. 32: 1481-1487.