In year 1, the Focus Group Neuroimaging staff will analyze selected existing data sets of FOR 1581, including re-analyses of fMRI data using normalization methods optimized for the cerebellum. They will also coordinate, prepare and optimize the acquisition of human neuroimaging data (rsfMRI and DTI). In years 2–4, meta-analytic approaches will be used to analyze the differential relationship between functional and structural connectivity and extinction learning across subprojects. State-of-the-art analysis procedures for structural and functional connectivity analysis as well as optimized normalization protocols of the cerebellum will be made accessible to all neuroimaging subprojects throughout the entire funding period.
Hypothesis of F02:
Bierbrauer A, Kunz L, Gomes CA, Luhmann M, Deuker L, Getzmann S, Wascher E, Gajewski PD, Hengstler JG, Fernandez-Alvarez M, Atienza M, Cammisuli DM, Bonatti F, Pruneti C, Percesepe A, Bellaali Y, Hanseeuw B, Strange BA, Cantero JL, Axmacher N (2020) Unmasking selective path integration deficits in Alzheimer’s disease risk carriers. Sci Adv. 6(35): eaba1394.
Dieckmann L, Cole S, Kumsta R (2020) Stress genomics revisited: gene co-expression analysis identifies molecular signatures associated with childhood adversity. Transl Psychiatry. 10(1): 34.
Ernst TM, Thürling M, Müller S, Kahl F, Maderwald S, Schlamann M, Boele H-J, Koekkoek SKE, Diedrichsen J, Zeeuw CI de, Ladd ME, Timmann D (2017) Modulation of 7 T fMRI Signal in the Cerebellar Cortex and Nuclei During Acquisition, Extinction, and Reacquisition of Conditioned Eyeblink Responses. Hum Brain Mapp. 38(8): 3957–3974.
Ernst TM, Brol AE, Gratz M, Ritter C, Bingel U, Schlamann M, Maderwald S, Quick HH, Merz CJ, Timmann D (2019) The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm. ELife. 8.
Gomes CA, Steiner KM, Ludolph N, Spisak T, Ernst TM, Mueller O, Göricke SL, Labrenz F, Ilg W, Axmacher N, Timmann D. Resection of cerebellar tumours causes widespread and functionally relevant white matter impairments. Hum Brain Mapp. 2021 Apr 15;42(6):1641-1656.
Kumsta R (2019) The role of epigenetics for understanding mental health difficulties and its implications for psychotherapy research. Psychol Psychother. 92(2): 190–207.
Kunz L, Schröder TN, Lee H, Montag C, Lachmann B, Sariyska R, Reuter M, Stirnberg R, Stöcker T, Messing-Floeter PC, Fell J, Doeller CF, Axmacher N (2015) Reduced grid-cell-like representations in adults at genetic risk for Alzheimer’s disease. Science. 350(6259): 430–433.
Lee H, Stirnberg R, Wu S, Wang X, Stöcker T, Jung S, Montag C, Axmacher N (2020) Genetic Alzheimer’s Disease Risk Affects the Neural Mechanisms of Pattern Separation in Hippocampal Subfields. Curr Biol. 30(21): 4201-4212.e3
Sicorello M, Dieckmann L, Moser D, Lux V, Luhmann M, Schlotz W, Kumsta R (2020) Oxytocin and the stress buffering effect of social company: a genetic study in daily life. Soc Cogn Affect Neurosci. 15(3): 293–301.
Thürling M, Kahl F, Maderwald S, Stefanescu MR, Schlamann M, Boele H-J, Zeeuw CI de, Diedrichsen J, Ladd ME, Koekkoek SKE, Timmann D (2015) Cerebellar cortex and cerebellar nuclei are concomitantly activated during eyeblink conditioning: a 7T fMRI study in humans. J Neurosci. 35(3): 1228–1239.