A01 A02 A03 A04 A05 A07 A09 A10 A11 A12 A13 A14 A18 A19 A21 F01 F02

F02 – Focus Group Neuroimaging: Extinction network connectivity across learning paradigms

Nikolai Axmacher, Dagmar Timmann-Braun, Harald H. Quick

In year 1, the Focus Group Neuroimaging staff will analyze selected existing data sets of FOR 1581, including re-analyses of fMRI data using normalization methods optimized for the cerebellum. They will also coordinate, prepare and optimize the acquisition of human neuroimaging data (rsfMRI and DTI). In years 2–4, meta-analytic approaches will be used to analyze the differential relationship between functional and structural connectivity and extinction learning across subprojects. State-of-the-art analysis procedures for structural and functional connectivity analysis as well as optimized normalization protocols of the cerebellum will be made accessible to all neuroimaging subprojects throughout the entire funding period.

Hypothesis of F02:

  • Functional and structural connectivity of the extinction network allow predicting inter-individual differences in the efficacy of extinction learning across paradigms.
  • Extinction of appetitive and aversive learning relies on partly distinct functional and structural connectivity patterns.
  • The cerebellum shows pronounced functional and structural connectivity with other areas of the extinction network. Connectivity patterns of different cerebellar subregions play specific roles for different aspects of extinction.
  • Functional and structural connectivity of the extinction network is systematically altered in patients with disturbed extinction.

Nikolai Axmacher

Projektleiter A02, A03, F02

Ruhr-Universität Bochum

Harald-H. Quick

Projektleiter A05, F02

Universität Duisburg-Essen

Dagmar Timmann-Braun

Projektleiterin A05, F02

Universität Duisburg-Essen

Carlos A. Gomes

Postdoc F02

Ruhr-Universität Bochum

Javier Schneider Penate

Doktorand F02

Ruhr-Universität Bochum

Robert Englert

Doktorand F02

Universität Duisburg-Essen

10 project-relevant publications

Axmacher N, Schmitz DP, Wagner T, Elger CE, Fell J (2008) Interactions between medial temporal lobe, prefrontal cortex, and inferior temporal regions during visual working memory: a combined intracranial EEG and functional magnetic resonance imaging study. J Neurosci. 28(29): 7304–7312.

Deuker L, Olligs J, Fell J, Kranz TA, Mormann F, Montag C, Reuter M, Elger CE, Axmacher N (2013) Memory consolidation by replay of stimulus-specific neural activity. J Neurosci. 33(49): 19373–19383.

Diedrichsen J, Maderwald S, Kuper M, Thürling M, Rabe K, Gizewski ER, Ladd ME, Timmann D (2011) Imaging the deep cerebellar nuclei: a probabilistic atlas and normalization procedure. Neuroimage. 54(3): 1786–1794.

Gratz M, Schlamann M, Goericke S, Maderwald S, Quick HH (2016) Evaluation of fast highly undersampled contrast-enhanced MR angiography (sparse CE-MRA) in intracranial applications – initial study. Eur Radiol. doi:10.1007/s00330-016-4398-z

Kremers NAW, Deuker L, Kranz TA, Oehrn C, Fell J, Axmacher N (2014) Hippocampal control of repetition effects for associative stimuli. Hippocampus. 24(7): 892–902.

Maderwald S, Thurling M, Kuper M, Theysohn N, Muller O, Beck A, Aurich V, Ladd ME, Timmann D (2012) Direct visualization of cerebellar nuclei in patients with focal cerebellar lesions and its application for lesion-symptom mapping. Neuroimage. 63(3): 1421–1431.

Staresina BP, Fell J, Do Lam ATA, Axmacher N, Henson RN (2012) Memory signals are temporally dissociated in and across human hippocampus and perirhinal cortex. Nat Neurosci. 15(8): 1167–1173.

Stefanescu MR, Dohnalek M, Maderwald S, Thürling M, Minnerop M, Beck A, Schlamann M, Diedrichsen J, Ladd ME, Timmann D (2015) Structural and functional MRI abnormalities of cerebellar cortex and nuclei in SCA3, SCA6 and Friedreich’s ataxia. Brain. 138(Pt 5): 1182–1197.