In year 1, the Focus Group Neuroimaging staff will analyze selected existing data sets of FOR 1581, including re-analyses of fMRI data using normalization methods optimized for the cerebellum. They will also coordinate, prepare and optimize the acquisition of human neuroimaging data (rsfMRI and DTI). In years 2–4, meta-analytic approaches will be used to analyze the differential relationship between functional and structural connectivity and extinction learning across subprojects. State-of-the-art analysis procedures for structural and functional connectivity analysis as well as optimized normalization protocols of the cerebellum will be made accessible to all neuroimaging subprojects throughout the entire funding period.
Hypothesis of F02:
Axmacher N, Schmitz DP, Wagner T, Elger CE, Fell J (2008) Interactions between medial temporal lobe, prefrontal cortex, and inferior temporal regions during visual working memory: a combined intracranial EEG and functional magnetic resonance imaging study. J Neurosci. 28(29): 7304–7312.
Deuker L, Olligs J, Fell J, Kranz TA, Mormann F, Montag C, Reuter M, Elger CE, Axmacher N (2013) Memory consolidation by replay of stimulus-specific neural activity. J Neurosci. 33(49): 19373–19383.
Diedrichsen J, Maderwald S, Kuper M, Thürling M, Rabe K, Gizewski ER, Ladd ME, Timmann D (2011) Imaging the deep cerebellar nuclei: a probabilistic atlas and normalization procedure. Neuroimage. 54(3): 1786–1794.
Gratz M, Schlamann M, Goericke S, Maderwald S, Quick HH (2016) Evaluation of fast highly undersampled contrast-enhanced MR angiography (sparse CE-MRA) in intracranial applications – initial study. Eur Radiol. doi:10.1007/s00330-016-4398-z
Kremers NAW, Deuker L, Kranz TA, Oehrn C, Fell J, Axmacher N (2014) Hippocampal control of repetition effects for associative stimuli. Hippocampus. 24(7): 892–902.
Maderwald S, Thurling M, Kuper M, Theysohn N, Muller O, Beck A, Aurich V, Ladd ME, Timmann D (2012) Direct visualization of cerebellar nuclei in patients with focal cerebellar lesions and its application for lesion-symptom mapping. Neuroimage. 63(3): 1421–1431.
Staresina BP, Fell J, Do Lam ATA, Axmacher N, Henson RN (2012) Memory signals are temporally dissociated in and across human hippocampus and perirhinal cortex. Nat Neurosci. 15(8): 1167–1173.
Stefanescu MR, Dohnalek M, Maderwald S, Thürling M, Minnerop M, Beck A, Schlamann M, Diedrichsen J, Ladd ME, Timmann D (2015) Structural and functional MRI abnormalities of cerebellar cortex and nuclei in SCA3, SCA6 and Friedreich’s ataxia. Brain. 138(Pt 5): 1182–1197.