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Treasure Box Funding for Laura Lückemann (A18): Extinction and Memory Up-Dating

Laura Lueckemann from the University of Duisburg-Essen is Post-Doc in the SFB 1280 subproject A18. The title of her research project is “Analysing extinction and memory up-dating of learned immune responses with fingolimod”. The objective of this study is to implement a new immunomodulatory drug in our conditioning paradigm allowing us to analyze not only behavioural readout parameters (CTA) during different time points of retrieval but also neuroendocrine and in particular immunological parameters, without sacrificing the animals.

Suppression of immune functions can be elicited by behavioral conditioning. However, it is still unknown, whether the effects of learned immunosuppression are restricted to calcineurin inhibitors such as CsA. Thus, in this project Laura will investigate whether conditioning of immune functions also applies for immunomodulating drugs with distinct cell signalling pathways, used for the treatment of multiple scleroses (fingomylod/FTY).

Laura hypothesizes that extinction of learned immunopharmacological effects can be abrogated by memory-updating mechanisms, using sub- or low-therapeutic drug doses during retrieval as reminder cues concomitantly with the CS. These data will provide the basis for employing learned immunopharmacological strategies in clinical situations as supportive therapy together with standard pharmacological regimen.

The SFB 1280 has set up a budget for the realisation of the research ideas of its young scientists. With the “treasure box”, we finance convincing and independent study concepts of young scientists.

New Year, New Me: The Facts

As the calendar turns to a new year, millions of people around the world commit to New Year’s resolutions, making promises to use the new year as a fresh beginning and an opportunity for transformation. In 2024, almost three-quarters of the British population set themselves New Year’s resolutions — that’s around 40 million people (or the entire population of Canada). This tradition was particularly strong among younger generations, with 96% of Generation Z (aged 18-27) planning resolutions, compared to just 35% of the Silent Generation (aged 79+).

Most common new years resolutions:

  1. Saving more money (52%)
  2. Eat healthier (50%)
  3. Exercise more (48%)
  4. Lose weight (37%)
  5. Spend more time with family/friends (35%)

How long do most resolutions normally last before being broken?

  • Data from America (2016) shows that 75% of individuals maintain their resolutions through the first week. 
  • 64% of individuals maintain their resolutions through the first month. 
  • 46% of individuals in America keep their resolutions past the 6-month mark.

What makes resolutions stick?

Oscarsson et al. (2020) conducted research into what makes New Year’s resolutions stick. Biggest success rates depended on how people phrased their goals. Participants who set approach-oriented goals (trying to move toward or maintain a desirable outcome or state) than those with avoidance-oriented goals (trying to move toward or maintain a desirable outcome or state) were significantly more successful (58.9% vs. 47.1%) at sticking to their goals.

The study also investigates the effects of outside support. These participants received monthly follow-ups and emails with information and exercises for coping with hurdles when striving toward personal goals, and were also encouraged to set goals using the SMART technique and to set interim goals. The group that received some support was exclusively and significantly more successful compared to the groups who received a lot of support or no support at all. 

Additionally, you might feel more successful if you set goals that are measurable in numbers. While success for a person striving to quit smoking or lose weight could easily be measured in the number of cigarettes smoked or body mass index, the success for a person striving to “take better care of themselves” could be highly subjective and possibly impossible to measure.

So as we enter 2026, let’s remember to work with our brain’s natural learning system: Frame your goals positively, break them into manageable steps, and celebrate small wins along the way.