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Pauline Bohne (A07) & Melanie Mark (A21): An off switch for aggression

The RUB news portal reports:

How aggressive behavior develops is still poorly understood. Researchers have now discovered a crucial piece of the puzzle.

Researchers from the Ruhr-Universität Bochum (RUB), together with colleagues from Bonn, have found a connection in the brain that is crucial for aggressive behavior in mice. The so-called P/Q-type calcium channel, which reacts to the neurotransmitter serotonin, is crucial. It has long been known that serotonin plays a key role in emotion regulation. But exactly how aggressive behavior arises has not been understood until now. If the researchers switched off the serotonin-mediated connection between two specific brain regions, the mice behaved less aggressively. The team led by Pauline Bohne (A07) and Prof. Dr. Melanie Mark (A21) report their findings in the Journal of Neuroscience, published online July 19, 2022.

Original article of the RUB: >>

Original article as PDF: >>

Scientific Paper: >>