A01 A02 A03 A04 A05 A06 A07 A08 A09 A10 A11 A12 A13 A14 A15 A16 A18 F01 F02

Controlling and Visualising Receptor Signals in Neural Cells (A07)

14. February 2019

This new tool is a true two-in-one solution. In future, it might help to study a number of diseases. Using a novel optogenetic tool, researchers have successfully controlled, reproduced and visualised serotonin receptor signals in neural cells. To this end, they modified a photosensitive membrane receptor in the eye, called melanopsin. The Press Department of the Ruhr-Universität Bochum reports on their news portal.

As a result, they were able to switch the receptor on and off using light; it also acted like a sensor indicating via fluorescence if specific signalling pathways in the cell had been activated. The sensor was, moreover, specifically designed to migrate to those domains in the neural cells that are sensitive to the neurotransmitter serotonin. The team from Ruhr-Universität Bochum, headed by Dennis Eickelbeck and Stefan Herlitze, described its project in the journal Nature Communications Biology on 14 February 2019.

Link

Article: >>