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New Method in Optogenetics (A07)

The press announces the new publication of A07: “Design of an ultrafast G protein switch based on a mouse melanopsin variant”. The paper proposes a generally applicable to designing optogenetic tools. The primary goal of optogenetics is the light‐controlled noninvasive and specific manipulation of various cellular processes.

So far, development has been mainly based on a trial-and-error approach. But the novel method might help save a lot of time. “I’m convinced that it will be possible to combine this new melanopsin variant with other optogenetic tools in future, in order to control complex cellular processes,” says Stefan Herlitze. Together with Raziye Karapinar, Melanie D. Mark and Katharina Spoida from A07 he established the new method in a cooperation with other groups.

“Unlike traditional protein engineering methods based on trial-and-error, our approach saves a lot of time thanks to automated computer-aided prognoses that can be calculated on several computers at the same time,” concludes Klaus Gerwert.

© RUB, Kramer

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New Year, New Me: The Facts

As the calendar turns to a new year, millions of people around the world commit to New Year’s resolutions, making promises to use the new year as a fresh beginning and an opportunity for transformation. In 2024, almost three-quarters of the British population set themselves New Year’s resolutions — that’s around 40 million people (or the entire population of Canada). This tradition was particularly strong among younger generations, with 96% of Generation Z (aged 18-27) planning resolutions, compared to just 35% of the Silent Generation (aged 79+).

Most common new years resolutions:

  1. Saving more money (52%)
  2. Eat healthier (50%)
  3. Exercise more (48%)
  4. Lose weight (37%)
  5. Spend more time with family/friends (35%)

How long do most resolutions normally last before being broken?

  • Data from America (2016) shows that 75% of individuals maintain their resolutions through the first week. 
  • 64% of individuals maintain their resolutions through the first month. 
  • 46% of individuals in America keep their resolutions past the 6-month mark.

What makes resolutions stick?

Oscarsson et al. (2020) conducted research into what makes New Year’s resolutions stick. Biggest success rates depended on how people phrased their goals. Participants who set approach-oriented goals (trying to move toward or maintain a desirable outcome or state) than those with avoidance-oriented goals (trying to move toward or maintain a desirable outcome or state) were significantly more successful (58.9% vs. 47.1%) at sticking to their goals.

The study also investigates the effects of outside support. These participants received monthly follow-ups and emails with information and exercises for coping with hurdles when striving toward personal goals, and were also encouraged to set goals using the SMART technique and to set interim goals. The group that received some support was exclusively and significantly more successful compared to the groups who received a lot of support or no support at all. 

Additionally, you might feel more successful if you set goals that are measurable in numbers. While success for a person striving to quit smoking or lose weight could easily be measured in the number of cigarettes smoked or body mass index, the success for a person striving to “take better care of themselves” could be highly subjective and possibly impossible to measure.

So as we enter 2026, let’s remember to work with our brain’s natural learning system: Frame your goals positively, break them into manageable steps, and celebrate small wins along the way.