A01 A02 A03 A04 A05 A06 A07 A09 A10 A11 A12 A13 A14 A18 A19 A21 F01 F02 INF Ö

A10 – From Pavlov to pain: extinction learning in visceral pain

Sigrid Elsenbruch, Adriane Icenhour

Impaired extinction of pain-related fear may contribute to the pathophysiology of chronic pain, but remains incompletely understood. This proposal aims to address mechanisms and clinical implications of extinction learning with a focus on interoceptive, visceral pain in healthy volunteers and patients with irritable bowel syndrome (IBS). We will address if impaired extinction learning is modality-specific for visceral pain in IBS. We will test if the stress hormone cortisol enhances the reinstatement of pain-related fear, and will implement a new paradigm of contextual interoceptive conditioning with visceral conditioned stimuli in order to address context-dependent extinction processes.

Guiding questions of A10:

  • Is altered learning and impaired extinction of pain-related fear specific to the visceral pain modality in patients with IBS?
  • Are interoceptive signals effective conditioned stimuli in a new contextual interoceptive conditioning paradigm?
  • Can we show reinstatement and renewal effects in this new paradigm?
  • Does the stress hormone cortisol impair pain-related extinction learning?
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Sigrid Elsenbruch

Project Lead A10, A12

Ruhr University Bochum

Adriane Icenhour

Project Lead A10

University of Duisburg-Essen

Franziska Labrenz

Postdoc A10, A12

Ruhr University Bochum / University of Duisburg-Essen

Genisius Hartanto

Postdoc A10

Ruhr University Bochum

Laura R. Lanters née Koenen

Postdoc A10

Ruhr University Bochum

Dominic Pundt

PhD Student A10

Ruhr University Bochum

Katharina Koch

PhD Student A10

Ruhr University Bochum

Cornelia Klukowski

PhD Student A10

Ruhr University Bochum

10 project-relevant publications

Icenhour A, Petrakova L, Hazzan N, Theysohn N, Merz CJ, Elsenbruch S (2021) When gut feelings teach the brain to fear pain: Context-dependent activation of the central fear network in a novel interoceptive conditioning paradigm. Neuroimage 238:118229. https://doi.org/10.1016/j.neuroimage.2021.118229 

Icenhour A, Kattoor J, Benson S, Boekstegers A, Schlamann M, Merz CJ, Forsting M, Elsenbruch S (2015a) Neural circuitry underlying effects of context on human pain-related fear extinction in a renewal paradigm. Hum Brain Mapp 36:3179–3193. https://doi.org/10.1002/hbm.22837

Icenhour A, Langhorst J, Benson S, Schlamann M, Hampel S, Engler H, Forsting M, Elsenbruch S (2015b) Neural circuitry of abdominal pain-related fear learning and reinstatement in irritable bowel syndrome. Neurogastroenterol Motil. 27:114–127. https://doi.org/10.1111/nmo.12489

Keefer L, Ballou SK, Drossman DA, Ringstrom G, Elsenbruch S, Ljótsson B (2022) A Rome Working Team Report on Brain-Gut Behavior Therapies for Disorders of Gut-Brain Interaction. Gastroenterology 162:300–315. https://doi.org/10.1053/j.gastro.2021.09.015

Koenen LR, Pawlik RJ, Icenhour A, Petrakova L, Forkmann K, Theysohn N, Engler H, Elsenbruch S (2021) Associative learning and extinction of conditioned threat predictors across sensory modalities. Commun Biol 4:553. https://doi.org/10.1038/s42003-021-02008-1 

Koenen LR, Icenhour A, Forkmann K, Theysohn N, Forsting M, Bingel U, Elsenbruch S (2018) From Anticipation to the Experience of Pain: The Importance of Visceral Versus Somatic Pain Modality in Neural and Behavioral Responses to Pain-Predictive Cues. Psychosom Med 80:826–835. https://doi.org/10.1097/PSY.0000000000000612

Labrenz F, Spisák T, Ernst TM, Gomes CA, Quick HH, Axmacher N, Elsenbruch S, Timmann D (2022a) Temporal dynamics of fMRI signal changes during conditioned interoceptive pain-related fear and safety acquisition and extinction. Behav Brain Res 427:113868. https://doi.org/10.1016/j.bbr.2022.113868 

Labrenz F, Icenhour A, Schlamann M, Forsting M, Bingel U, Elsenbruch S (2016) From Pavlov to pain: How predictability affects the anticipation and processing of visceral pain in a fear conditioning paradigm. Neuroimage 130:104–114. https://doi.org/10.1016/j.neuroimage.2016.01.064

Lanters LR, Öhlmann H, Langhorst J, Theysohn N, Engler H, Icenhour A*, Elsenbruch S* (2024) Disease-specific alterations in central fear network engagement during acquisition and extinction of conditioned interoceptive fear in inflammatory bowel disease. Mol Psychiatry 29:3527–3536. (*equal contribution) https://doi.org/10.1038/s41380-024-02612-7 

Öhlmann H, Lanters LR, Theysohn N, Langhorst J, Engler H, Icenhour A, Elsenbruch S (2023) Distinct Alterations in Central Pain Processing of Visceral and Somatic Pain in Quiescent Ulcerative Colitis Compared to Irritable Bowel Syndrome and Health. J Crohns Colitis 17:1639–1651. https://doi.org/10.1093/ecco-jcc/jjad080